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Access to clean water is one of the most important factors considered in selection and development of a pharmaceutical manufacturing facility. Without readily available appropriately clean water, processing would be nearly impossible, changeover and cleaning of reusable equipment would cease, and overall production would grind to a stop.
Ozone is an extremely powerful and effective sanitizer increasingly used by pharmaceutical companies because it quickly kills bacteria and leaves no residual or by-products after the disinfection process. The properties of dissolved ozone gas are unique and may be somewhat unfamiliar to people who normally deal with temperature or liquid chemical sanitation methods.
Ozone is different than most sanitizers because it is a gas and remains a dissolved gas during the sanitization process for water systems. Dissolving ozone into water makes for a very potent antimicrobial solution, which can then be used as a sanitizing agent. Ozone is extremely fast at eliminating microbiological activity in the water at relatively low doses and has the advantage of being able to reach every part of the water system before being easily removed.
Unlike chemicals, which must be rinsed out with excessive amounts of water and require hazardous chemical disposal, there is no "handling" required of
ozone. The ability to operate at room temperature eliminates the need for expensive and complex heating systems and heat tracing on pipes that can be expensive to maintain and difficult to work around. The use of ozone for sanitation can offer increased product quality and lower the risk of water-borne
contaminants.
Ozone is used as an alternative to heat sanitization with hot water and steam or chemical disinfection using chlorine, chlorides, peroxides and other chemicals. It is one of the strongest commercially available oxidants, with a disinfecting strength 3,000 times that of chlorine. Ozone effectively kills bacteria, viruses, yeast, fungi and other microbes as a function of time, susceptibility of the target organisms(action), ozone concentration and water temperature. While there are a number of potential sources of contamination in storage and delivery systems for purified and sterile water, one of the most common problems facing purified water (PW) production and delivery is the prevention and removal of biofilms. Biofilms occur in a wide variety of systems, but are endemic to water systems in the biopharmaceutical industry. As a non-specific biocide, ozone reacts rapidly with most hydrocarbons to effectively destroy the biofilms’ EPS, and the microbes and organic residue material within these films.
Ozone's disinfecting ability to inhibit microbiological growth in a polymer solution for the pharmaceutical industry has been proven in several locations.
Polymers are often added to process water to get desired characteristics such as lubrication, cooling or preservative effect. The process waters lifespan is
limited in many cases by the microbiological growth which leading to increased costs followed by frequent replacement of the water, disinfection demands, more chemicals and unproductive work. We could through a series of successful laboratory tests, show the possibility of decreasing the microbiological activity and thus prolonging the polymer solutions lifespan. The Ozone treatment inhibited the gram positive yeast fungi to proliferate, and thus taking longer to reach the max CFU limits. The solution's lifespan is prolonged.
Effluent waste water from an industrial facility may carry a broad and variable range of contaminants, including BOD, COD, colour, phenols, cyanides, sanitary waste and a host of complex chemicals. Ozone, in combination with other physical, chemical or biological processes, has the potential to treat complex industrial wastes due to its strong oxidative nature. In combination with medium pressure UV, Ozone exhibits the power of advanced oxidation for TOC reduction, as well as destruction of organics. Potential industries that can benefit from Ozone include pharmaceuticals, textiles, automotive, foundry, etc. Waste waters from pharmaceutical industries are complex, with a variable nature. The waste water generated from pharmaceutical industry generally liquid – based waste water generated in the various processes like, fermentation, extraction, chemical synthesis. Waste water consists of high organic content thereby making the waste water as high COD waste water.
Ozone Treatment for Green Sustainable Pharmaceutical Waste Water Treatment Recycling
The use of Ozone in the treatment of pharmaceutical waste water is attractive mainly because it may achieve the complete conversion of pollutants to CO2
and H2O, reducing toxicity and improving biodegradability.
